Antidepressant Drugs MCQs with Answers Free 2022

In this post , the Multiple Choice Questions regarding Antidepressant Drugs are given with answers for Practice. These Multiple Choice Questions are important on the Exam point of view. These MCQs can be very useful for exams like GPAT, NIPER, B- Pharma, D-Pharma and many more  similar examinations.

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Antidepressant Drugs MCQs with Answers Free 2022 [Practice Now]


  1. The principal mechanism of action of antidepressant agents is:
    a) Stabilization of dopamine and beta-adrenergic receptors
    b) Inhibition of the storage of serotonin and epinephrine in the vesicles of presynaptic nerve endings
    c) Blocking epinephrine or serotonin reuptake pumps
    d) Stimulation of alfa2-norepinephrine receptors
  2. Which of the following agents is related to tricyclic antidepressants?
    a) Nefazodon
    b) Amitriptyline
    c) Fluoxetine
    d) Isocarboxazid
  3. Indicate the second-generation heterocyclic drug:
    a) Maprotiline
    b) Imipramine
    c) Phenelzine
    d) Fluoxetine
  4. Which of the following agents is related to the third-generation heterocyclic antidepressants?
    a) Amitriptyline
    b) Maprotiline
    c) Nefazodone
    d) Tranylcypromine
  5. Which of the following antidepressants is a selective serotonin reuptake inhibitor?
    a) Phenelzine
    b) Desipramine
    c) Maprotiline
    d) Fluoxetine
  6. Which of the following antidepressant agents is a selective inhibitor of norepinephrine reuptake?
    a) Fluvoxamine
    b) Maprotiline
    c) Amitriptyline
    d) Tranylcypromine
  7. Indicate the antidepressant, which blocks the reuptake pumps for serotonin and norepinephrine:
    a) Amitriptyline
    b) Fluoxetine
    c) Maprotiline
    d) Phenelzine
  8. Which of the following antidepressants is an unselective MAO blocker and produces extremely long-lasting inhibition of
    the enzyme?
    a) Moclobemide
    b) Tranylcypramine
    c) Selegiline
    d) Fluoxetine
  9. Indicate the irreversible MAO inhibitor, which is a hydrazide derivative:
    a) Moclobemide
    b) Selegiline
    c) Tranylcypramine
    d) Phenelzine
  10. Which of the following MAO inhibitors has amphetamine-like activity and is related to nonhydrazide derivatives:
    a) Phenelzine
    b) Moclobemide
    c) Tranylcypramine
    d) All of the above
  11. Which of the following antidepressants is a selective short-acting MAO-A inhibitor?
    a) Maprotiline
    b) Amitriptyline
    c) Moclobemide
    d) Selegiline
  12. Monoamine Oxydase A:
    a) Is responsible for norepinephrine, serotonin, and tyramine metabolism
    b) Is more selective for dopamine
    c) Metabolizes norepinephrine and dopamine
    d) Deaminates dopamine and serotonin
  13. Which synapses are involved in depression?
    a) Dopaminergic synapses
    b) Serotoninergic synapses
    c) Cholinergic synapses
    d) All of the above
  14. Block of which type of Monoamine Oxydase might be more selective for depression?
    a) MAO-A
    b) MAO-B
    c) Both MAO-A and MAO-B
    d) MAO-C
  15. The principal mechanism of MAO inhibitor action is:
    a) Blocking the amine reuptake pumps, which permits to increase the concentration of the neurotransmitter at the
    receptor site
    b) Blocking a major degradative pathway for the amine neurotransmitters, which permits more amines to
    accumulate in presynaptic stores
    c) Inhibition the storage of amine neurotransmitters in the vesicles of presynaptic nerve endings
    d) Antagonism of alfa2-norepinephrine receptors
  16. The irreversible MAO inhibitors have a very high risk of developing:
    a) Respiratory depression
    b) Cardiovascular collapse and CNS depression
    c) Hypertensive reactions to tyramine ingested in food
    d) Potentially fatal agranulocytosis
  17. The most dangerous pharmacodynamic interaction is between MAO inhibitors and:
    a) Selective serotonin reuptake inhibitors
    b) Tricyclics
    c) Sympathomimetics
    d) All of the above
  18. Serotonin syndrome is a result of:
    a) Increased stores of monoamine
    b) Significant accumulation of amine neurotransmitters in the synapses
    c) Both a and b
    d) Depleted stores of biogenic amines
  19. The therapeutic response to antidepressant drugs is usually over a period of:
    a) 2-3 days
    b) 2-3 weeks
    c) 24 hours
    d) 2-3 month
  20. Which of the following antidepressants may have latency period as short as 48 hours?
    a) Tranylcypromine
    b) Imipramine
    c) Fluoxetine
    d) Amitrityline
  21. Which of the following features do MAO inhibitors and tricyclic antidepressants have in common?
    a) Act postsynaptically to produce their effect
    b) Can precipitate hypotensive crises if certain foods are ingested
    c) Increase levels of biogenic amines
    d) Are useful for the manic phase of bipolar disorder
  22. Tricyclic antidepressants are:
    a) Highly selective serotonin reuptake inhibitors
    b) Monoamine oxidase inhibitors
    c) Selective norepinephrine reuptake inhibitors
    d) Mixed norepinephrine and serotonin reuptake inhibitors
  23. Which of the following autonomic nervous system effects is common for tricyclic antidepressants?
    a) Antimuscarinic action
    b) Antihistaminic action
    c) Alfa adrenoreceptor-blocking action
    d) All of the above
  24. Indicate an effective antidepressant with minimal autonomic toxicity:
    a) Amitrityline
    b) Fluoxetine
    c) Imipramine
    d) Doxepin
  25. Fluoxetine has fewer adverse effects because of:
    a) Mixed norepinephrine and serotonin reuptake inhibition
    b) Depleted stores of amine neurotransmitters
    c) Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors
    d) All of the above
  26. Which of the following tricyclic and heterocyclic antidepressants has the greatest sedation?
    a) Doxepin
    b) Amitriptyline
    c) Trazodone
    d) All of the above
  27. Which of the following tricyclic and heterocyclic agents has the least sedation?
    a) Protriptyline
    b) Trazodone
    c) Amitriptyline
    d) Mitrazapine
  28. Indicate a tricyclic or a heterocyclic antidepressant having greatest antimuscarinic effects:
    a) Desipramine
    b) Amitriptyline
    c) Trazodone
    d) Mirtazapine
  29. Indicate a tricyclic or a heterocyclic antidepressant having least antimuscarinic effects:
    a) Trazodone
    b) Buprorion
    c) Mirtazapine
    d) All of the above
  30. Which of the following antidepressants has significant alfa2-adrenoreceptor antagonism?
    a) Amitriptyline
    b) Nefazodone
    c) Mirtazapine
    d) Doxepin
  31. Indicate the main claim for an ideal antidepressant agent:
    a) A faster onset of action
    b) Fewer adverse sedative and autonomic effects
    c) Fewer toxicity when overdoses are taken
    d) All of the above
  32. Sedation, peripheral atropine-like toxicity (e.g. Cycloplegia, tachycardia, urinary retention, and constipation), orthostatic hypotension, arrhythmias, weight gain and sexual disturbances are possible adverse effects of:
    a) Sertaline
    b) Amitriptyline
    c) Phenelsine
    d) Bupropion
  33. Which of the following drugs is least likely to be prescribed to patients with prostatic hypertrophy, glaucoma, coronary and cerebrovascular disease?
    a) Amitriptyline
    b) Paroxetine
    c) Bupropion
    d) Fluoxetine
  34. Indicate the antidepressant agent, which is a phenyltolylpropylamine derivative:
    a) Paroxetine
    b) Maprotiline
    c) Fluoxetine
    d) Amitriptyline
  35. The mechanism of fluoxetine action includes:
    a) Selective inhibition of serotonine uptake in the CNS
    b) Little effect on central norepinephrine or dopamine function
    c) Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors
    d) All of the above
  36. Which of the following antidepressants is used for treatment of eating disorders, especially buliemia?
    a) Amitriptyline
    b) Fluoxetine
    c) Imipramine
    d) Tranylcypromine
  37. Sertaline and paroxetine are similar to fluoxetine in the mechanism of action and therapeutic use, sertaline is less likely to interact adversely with other drugs.
    a) True
    b) False
  38. A highly selective serotonine reuptake inhibitor is:
    a) Sertaline
    b) Paroxetine
    c) Fluoxetine
    d) All of the above

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Antidepressant Drugs MCQs with Answers Free 2022 : ANSWER KEY

If you find any Question or Answer wrong , then you can mention in the comment below.

01. –   c   11. –   c   21. –   c   31. –   d 
02. –   b   12. –   a   22. –   d   32. –   b  
03. –   a   13. –   b   23. –   d   33. –   a  
04. –   c   14. –   a   24. –   b   34. –   c
05. –   d   15. –   b   25. –   c   35. –   d  
06. –   b   16. –   c   26. –   d   36. –   b 
07. –   a   17. –   d   27. –   a   37. –   a  
08. –   b   18. –   c   28. –   b   38. –   d  
09. –   d   19. –   d   29. –   d 
10. –   c   20. –   a   30. –   c   

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