Antiseizure Drugs MCQs with Answers Free 2022

Anti-seizure medicines work by reducing the abnormal electrical activity in the brain that is causing the seizures. Different medicines do this in different ways, and some work better for certain kinds of seizures than others. Practice Here the Antiseizure Drugs Multiple Choice Questions which are very useful from the Examination point of view of GPAT, NIPER, B- Pharma , D-Pharma etc.

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In this Series of Practice you will get a lots of Topic-wise Multiple Choice Questions for your Exams. If you haven’t find MCQ post regarding any topic, what you want then feel free to mention below. Now Practice Antiseizure Drugs MCQs in this post.


Antiseizure Drugs MCQs with Answers Free 2022 [Practice Now]


  1. The mechanism of action of antiseizure drugs is:
    a) Enhancement of GABAergic (inhibitory) transmission
    b) Diminution of excitatory (usually glutamatergic) transmission
    c) Modification of ionic conductance
    d) All of the above mechanisms
  2. Which of the following antiseizure drugs produces enhancement of GABA-mediated inhibition?
    a) Ethosuximide
    b) Carbamazepine
    c) Phenobarbital
    d) Lamotrigine
  3. Indicate an antiseizure drug, which has an impotent effect on the T-type calcium channels in thalamic neurons?
    a) Carbamazepin
    b) Lamotrigine
    c) Ethosuximide
    d) Phenytoin
  4. Which of the following antiseizure drugs produces a voltage-dependent inactivation of sodium channels?
    a) Lamotrigine
    b) Carbamazepin
    c) Phenytoin
    d) All of the above
  5. Indicate an antiseizure drug, inhibiting central effects of excitatory amino acids:
    a) Ethosuximide
    b) Lamotrigine
    c) Diazepam
    d) Tiagabine
  6. The drug for partial and generalized tonic-clonic seizures is:
    a) Carbamazepine
    b) Valproate
    c) Phenytoin
    d) All of the above
  7. Indicate an anti-absence drug:
    a) Valproate
    b) Phenobarbital
    c) Carbamazepin
    d) Phenytoin
  8. The drug against myoclonic seizures is:
    a) Primidone
    b) Carbamazepine
    c) Clonazepam
    d) Phenytoin
  9. The most effective drug for stopping generalized tonic-clonic status epilepticus in adults is:
    a) Lamotrigine
    b) Ethosuximide
    c) Diazepam
    d) Zonisamide
  10. Select the appropriate consideration for phenytoin:
    a) It blocks sodium channels
    b) It binds to an allosteric regulatory site on the GABA-BZ receptor and prolongs the openings of the Clchannels
    c) It effects on Ca2+ currents, reducing the low-threshold (T-type) current
    d) It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
  11. Phenytoin is used in the treatment of:
    a) Petit mal epilepsy
    b) Grand mal epilepsy
    c) Myoclonic seizures
    d) All of the above
  12. Dose-related adverse effect caused by phenytoin is:
    a) Physical and psychological dependence
    b) Exacerbated grand mal epilepsy
    c) Gingival hyperplasia
    d) Extrapyramidal symptoms
  13. Granulocytopenia, gastrointestinal irritation, gingival hyperplasia, and facial hirsutism are possible adverse effects of:
    a) Phenobarbital
    b) Carbamazepin
    c) Valproate
    d) Phenytoin
  14. The antiseizure drug, which induces hepatic microsomal enzymes, is:
    a) Lamotrigine
    b) Phenytoin
    c) Valproate
    d) None of the above
  15. The drug of choice for partial seizures is:
    a) Carbamazepin
    b) Ethosuximide
    c) Diazepam
    d) Lamotrigine
  16. The mechanism of action of carbamazepine appears to be similar to that of:
    a) Benzodiazepines
    b) Valproate
    c) Phenytoin
    d) Ethosuximide
  17. Which of the following antiseizure drugs is also effective in treating trigeminal neuralgia?
    a) Primidone
    b) Topiramat
    c) Carbamazepine
    d) Lamotrigine
  18. The most common dose-related adverse effects of carbamazepine are:
    a) Diplopia, ataxia, and nausea
    b) Gingival hyperplasia, hirsutism
    c) Sedation, physical and psychological dependence
    d) Hemeralopia, myasthenic syndrome
  19. Indicate the drug of choice for status epilepticus in infants and children:
    a) Phenobarbital sodium
    b) Clonazepam
    c) Ethosuximide
    d) Phenytoin
  20. Barbiturates are used in the emergency treatment of status epilepticus in infants and children because of:
    a) They significantly decrease of oxygen utilization by the brain, protecting cerebral edema and ischemia
    b) Short onset and duration of action
    c) They do not have effect on sleep architecture
    d) All of the above
  21. Which of the following antiseizure drugs binds to an allosteric regulatory site on the GABA-BZ receptor, increases the
    duration of the Clchannels openings:
    a) Diazepam
    b) Valproate
    c) Phenobarbital
    d) Topiramate
  22. Adverse effect caused by phenobarbital is:
    a) Physical and phychological dependence
    b) Exacerbated petit mal epilepsy
    c) Sedation
    d) All of the above
  23. Which of the following antiseizure drugs is a prodrug, metabolized to phenobarbital?
    a) Phenytoin
    b) Primidone
    c) Felbamate
    d) Vigabatrin
  24. Indicate the antiseizure drug, which is a phenyltriazine derivative:
    a) Phenobarbital
    b) Clonazepam
    c) Lamotrigine
    d) Carbamazepin
  25. Lamotrigine can be used in the treatment of:
    a) Partial seizures
    b) Absence
    c) Myoclonic seizures
    d) All of the above
  26. The mechanism of vigabatrin′s action is:
    a) Direct action on the GABA receptor-chloride channel complex
    b) Inhibition of GABA aminotransferase
    c) NMDA receptor blockade via the glycine binding site
    d) Inhibition of GABA neuronal reuptake from synapses
  27. Indicate an irreversible inhibitor of GABA aminotransferase (GABA-T):
    a) Diazepam
    b) Phenobarbital
    c) Vigabatrin
    d) Felbamate
  28. Tiagabine:
    a) Blocks neuronal and glial reuptake of GABA from synapses
    b) Inhibits GABA-T, which catalyzed the breakdown of GABA
    c) Blocks the T-type Ca2+ channels
    d) Inhibits glutamate transmission at AMPA/kainate receptors
  29. The mechanism of both topiramate and felbamate action is:
    a) Reduction of excitatory glutamatergic neurotransmission
    b) Inhibition of voltage sensitive Na+ channels
    c) Potentiation of GABAergic neuronal transmission
    d) All of the above
  30. The drug of choice in the treatment of petit mal (absence seizures) is:
    a) Phenytoin
    b) Ethosuximide
    c) Phenobarbital
    d) Carbamazepin
  31. The dose-related adverse effect of ethosuximide is:
    a) Gastrointestinal reactions, such as anorexia, pain, nausea and vomiting
    b) Exacerbated grand mal epilepsy
    c) Transient lethargy or fatigue
    d) All of the above
  32. Valproate is very effective against:
    a) Absence seizures
    b) Myoclonic seizures
    c) Generalized tonic-clonic seizures
    d) All of the above
  33. The drug of choice in the treatment of myoclonic seizures is:
    a) Valproate
    b) Phenobarbital
    c) Phenytoin
    d) Felbamate
  34. The reason for preferring ethosuximide to valproate for uncomplicated absence seizures is:
    a) More effective
    b) Valproate′s idiosyncratic hepatotoxicity
    c) Greater CNS depressant activity
    d) All of the above
  35. The mechanism of valproate action is:
    a) Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABAaminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation)
    b) Inhibition of voltage sensitive Na+ channels
    c) Inhibition of low threshold (T-type) Ca2+ channels
    d) All of the above
  36. Indicate the antiseizure drug, which is a sulfonamide derivative, blocking Na+
    channels and having additional ability to inhibit T-type Ca2+ channels:
    a) Tiagabine
    b) Zonisamide
    c) Ethosuximide
    d) Primidone
  37. Indicate the antiseizure drug – a benzodiazepine receptor agonist:
    a) Phenobarbital
    b) Phenytoin
    c) Carbamazepine
    d) Lorazepam
  38. Which of the following antiseizure drugs acts directly on the GABA receptor-chloride channel complex?
    a) Vigabatrin
    b) Diazepam
    c) Gabapentin
    d) Valproate
  39. Benzodiazepine΄s uselfulness is limited by:
    a) Tolerance
    b) Atropine-like symptoms
    c) Psychotic episodes
    d) Myasthenic syndrome
  40. A long-acting drug against both absence and myoclonic seizures is:
    a) Primidone
    b) Carbamazepine
    c) Clonazepam
    d) Phenytoin
  41. Which of the following antiseizure drugs may produce teratogenicity?
    a) Phenytoin
    b) Valproate
    c) Topiramate
    d) All of the above
  42. The most dangerous effect of antiseizure drugs after large overdoses is:
    a) Respiratory depression
    b) Gastrointestinal irritation
    c) Alopecia
    d) Sedation

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Antiseizure Drugs MCQs with Answers Free 2022 : ANSWER KEY

If you find any Question or Answer wrong , then you can mention in the comment below.

01. –   d   11. –   b   21. –   c   31. –   d     41. –  d    
02. –   c   12. –   c   22. –   d   32. –   d     42. –  a   
03. –   c   13. –   d   23. –   b   33. –   a  
04. –   d   14. –   b   24. –   c   34. –   b
05. –   b   15. –   a   25. –   d   35. –   d 
06. –   d   16. –   c   26. –   b   36. –   b
07. –   a   17. –   c   27. –   c   37. –   d  
08. –   c   18. –   a   28. –   a   38. –   b 
09. –   c   19. –   a   29. –   d   39. –   a
10. –   a   20. –   a   30. –   b   40. –   c 

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