Cholinomimetic Drugs MCQs with Answers Free 2022

Cholinomimetics drugs are those drugs that cause effects similar to those resulting from introduction of acetylcholine, or simulation of ganglions of the parasympathetic nervous system. These drugs imitate action of endogenously released acetylcholine. Cholinomimetics or Cholinergic drugs stimulate the parasympathetic nervous system by copying the action of Ach. They are given for Alzheimer’s disease, glaucoma, paralytic ileus, urinary retention, and myasthenia gravis.

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So, the Multiple Choice Questions in this post will clear all the doubts and make a strong grip on this Chapter/topic. It is also helpful  for several   Examinations  like B-Pharma, D-Pharma, GPAT, NIPER and many more. Then Practice these Given MCQs  and take your preparation to the  another level.


Cholinomimetic Drugs MCQs with Answers Free 2022 [Practice Now]


  1. Acetylcholine is not a specific neurotransmitter at:
    a) Sympathetic ganglia
    b) Sympathetic postganglionic nerve endings
    c) Parasympathetic ganglia
    d) Parasympathetic postganglionic nerve endings
  2. Muscarinic receptors are located in:
    a) Autonomic ganglia
    b) Skeletal muscle neuromuscular junctions
    c) Autonomic effector cells
    d) Sensory carotid sinus baroreceptor zone
  3. Indicate the location of M2 cholinoreceptor type:
    a) Heart
    b) Glands
    c) Smooth muscle
    d) Endothelium
  4. The symptoms of mushroom poisoning include all of the following EXCEPT:
    a) Salivation, lacrimation, nausea, vomiting
    b) Dryness of mouth, hyperpyrexia, hallucination
    c) Headache, abdominal colic
    d) Bradycardia, hypotension and shock
  5. Which of the following cholinomimetics activates both muscarinic and nicotinic receptors?
    a) Lobeline
    b) Pilocarpine
    c) Nicotine
    d) Bethanechol
  6. Indicate a cholinomimetic agent, which is related to direct-acting drugs:
    a) Edrophonium
    b) Physostigmine
    c) Carbachol
    d) Isoflurophate
  7. Characteristics of carbachol include all of the following EXCEPT:
    a) It decreases intraocular pressure
    b) It causes mydriasis
    c) It exerts both nicotinic and muscarinic effects
    d) It is resistant to acethylcholiesterase
  8. Acetylcholine is not used in clinical practice because:
    a) It is very toxic
    b) The doses required are very high
    c) It is very rapidly hydrolyzed
    d) It is very costly
  9. Parasympathomimetic drugs cause:
    a) Bronchodilation
    b) Mydriasis
    c) Bradycardia
    d) Constipation
  10. Which of the following direct-acting cholinomimetics is mainly muscarinic in action?
    a) Bethanechol
    b) Carbachol
    c) Acetylcholine
    d) None of the above
  11. Which of the following direct-acting cholinomimetics has the shortest duration of action?
    a) Acetylcholine
    b) Methacholine
    c) Carbachol
    d) Bethanechol
  12. Bethanechol has all of the following properties EXCEPT:
    a) It is extremely resistant to hydrolysis
    b) Purely muscarinic in its action
    c) It is used for abdominal urinary bladder distention
    d) It exerts both nicotinic and muscarinic effects
  13. A M-cholinimimetic agent is:
    a) Carbachol
    b) Pilocarpine
    c) Acetylcholine
    d) Bethanechol
  14. Characteristics of pilocarpine include all of the following EXCEPT:
    a) It is a tertiary amine alkaloid
    b) It causes miosis and a decrease in intraocular pressure
    c) Causes a decrease in secretory and motor activity of gut
    d) It is useful in the treatment of glaucoma
  15. Which of the following cholinomimetics is a plant derivative with lower potency than nicotine but with a similar spectrum of action?
    a) Lobeline
    b) Pilocarpine
    c) Carbochol
    d) Acetylcholine
  16. Which of the following cholinomimetics is indirect-acting?
    a) Lobeline
    b) Edrophonium
    c) Pilocarpine
    d) Carbachol
  17. The mechanism of action of indirect-acting cholinomimetic agents is:
    a) Binding to and activation of muscarinic or nicotinic receptors
    b) Inhibition of the hydrolysis of endogenous acetylcholine
    c) Stimulation of the action of acetylcholinesterase
    d) Releasing acetylcholine from storage sites
  18. Indicate a reversible cholinesterase inhibitor:
    a) Isoflurophate
    b) Carbochol
    c) Physostigmine
    d) Parathion
  19. Which of the following cholinesterase inhibitors is irreversible?
    a) Physostigmine
    b) Edrophonium
    c) Neostigmine
    d) Isoflurophate
  20. Indicate cholinesterase activator:
    a) Pralidoxime
    b) Edrophonium
    c) Pilocarpine
    d) Isoflurophate
  21. Isofluorophate increases all of the following effects except:
    a) Lacrimation
    b) Bronchodilation
    c) Muscle twitching
    d) Salivation
  22. Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect:
    a) Edrophonium
    b) Carbochol
    c) Neostigmine
    d) Lobeline
    18
  23. Сholinesterase inhibitors do not produce:
    a) Bradycardia, no change or modest fall in blood pressure
    b) Increased strength of muscle contraction, especially in muscles weakened by myasthenia gravis
    c) Miosis and reduction of intraocular pressure
    d) Dramatic hypertension and tachycardia
  24. Which of the following cholinomimetics is commonly used in the treatment of glaucoma?
    a) Pilocarpine
    b) Lobeline
    c) Acethylcholine
    d) Neostigmine
  25. Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmic use and retains its activity within a week:
    a) Physoctigmine
    b) Edrophonium
    c) Echothiophate
    d) Neostigmine
  26. Which of the following cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?
    a) Lobeline
    b) Neostigmine
    c) Pilocarpine
    d) Echothiophate
  27. Chronic long-term therapy of myasthenia is usually accomplished with:
    a) Edrophonium
    b) Neostigmine
    c) Echothiophate
    d) Carbachol
  28. Which of the following cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscular
    relaxants?
    a) Echothiophate
    b) Physostigmine
    c) Edrophonium
    d) Pilocarpine
  29. Indicate the reversible cholinesterase inhibitor, which penetrates the blood-brain barrier:
    a) Physostigmine
    b) Edrophonium
    c) Neostigmine
    d) Piridostigmine
  30. Which of the following cholinomimetics is used in the treatment of atropine intoxication?
    a) Neostigmine
    b) Carbochol
    c) Physostigmine
    d) Lobeline
  31. The symptoms of excessive stimulation of muscarinic receptors include all of the following EXCEPT:
    a) Abdominal cramps, diarrhea
    b) Increased salivation, excessive bronchial secretion
    c) Miosis, bradycardia
    d) Weakness of all skeletal muscles
  32. The excessive stimulation of muscarinic receptors by pilocarpine and choline esters is blocked competitively by:
    a) Edrophonium
    b) Atropine
    c) Pralidoxime
    d) Echothiophate
  33. The toxic effects of a large dose of nicotine include all of the following EXCEPT:
    a) Hypotension and bradycardia
    b) Convulsions, coma and respiratory arrest
    c) Skeletal muscle depolarization blockade and respiratory paralysis
    d) Hypertension and cardiac arrhythmias
  34. The dominant initial sights of acute cholinesterase inhibitors intoxication include all of the following except:
    a) Salivation, sweating
    b) Mydriasis
    c) Bronchial constriction
    d) Vomiting and diarrhea
  35. Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?
    a) Atropine
    b) Pilocarpine
    c) Pralidoxime
    d) Edrophonium

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Cholinomimetic Drugs MCQs with Answers Free 2022 : ANSWER KEY

If you find any Question or Answer wrong , then you can mention in the comment below.

01. –   b   11. –   a   21. –   b   31. –   d   
02. –   c   12. –   a   22. –   c   32. –   b  
03. –   a   13. –   d   23. –   d   33. –   a  
04. –   b   14. –   c   24. –   a   34. –   b  
05. –   d   15. –   a   25. –   c   35. –   c  
06. –   c   16. –   b   26. –   b  
07. –   b   17. –   b   27. –   b  
08. –   c   18. –   c   28. –   c  
09. –   d   19. –   d   29. –   a  
10. –   c   20. –   a   30. –   c  

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