GPAT Pharmaceutical Chemistry Syllabus PDF Download Free 2022

GPAT Pharmaceutical Chemistry Syllabus PDF Download | GPAT Pharmaceutical Chemistry Syllabus download

Download GPAT Pharmaceutical Chemistry Syllabus

GPAT Pharmaceutical chemistry Syllabus PDF Download Free

In this Syllabus post of Pharmaceutical Chemistry for GPAT exam , which is a national level entrance exam for those students who want to take admission into a good college or university across the country for Pharmacy courses. GPAT stands for Graduate Pharmacy Aptitude Test so only those students  are eligible  for this entrance test who have  done their graduation with a good marks form Science stream. So, for every exam syallbus is one the primary  thing to crack the exam, that’s  why here you will get GPAT Pharmaceutical Chemistry Syllabus in very  detailed form.

The major topics contains in GPAT Pharmaceutical Chemistry Syllabus are Pharmaceutical Impurities, Monographs, Isotopes, Dentifrices, desensitizing agents, & anticaries agents, Therapeutic classes of drugs, Various classes of therapeutic agents, Different classes of therapeutic drugs etc. Below the full detailed GPAT Pharmaceutical Chemistry Syllabus is given : –

Detailed GPAT Pharmaceutical Chemistry Syllabus

PHARMACEUTICAL CHEMISTRY

I. Pharmaceutical Inorganic Chemistry

1. Pharmaceutical Impurities

Impurities in pharmaceutical substances, sources, types & effects of impurities. Limit tests for heavy metals like lead, iron, arsenic, mercury & for chloride & sulphate as per Indian Pharmacopoeia [I. P.].

2. Monographs

Monograph & its importance, various tests included in monographs as per I. P. A study of the following compounds with respect to their methods of preparation, assay, & pharmaceutical uses of sodium citrate, calcium carbonate, copper sulphate, light & heavy kaolin, ammonium chloride & ferrous gluconate.

3. Isotopes

Isotopes- stable & radioactive, mode & rate of decay. Types & measurement of radioactivity. Radiopharmaceuticals & their diagnostic & therapeutic applications in pharmacy & medicine  such as 125I, 32P, 51Cr, 60Co, 59Fe, 99Tc-M. Radiocontrast media, use of BaSO4 in medicine.

4. Dentifrices, desensitizing agents, & anticaries agents

II. Medicinal Chemistry

5. Therapeutic classes of drugs

The following topics should be dealt with covering nomenclature [including stereochemical aspects], biological activity [including side & toxic effects], mode of action, structure-activityrelationship [where ever applicable] & syntheses of reasonable molecules.

  • General anesthetics.
  • Local anesthetics.
  • Diagnostic agents.
  • Coagulants, anticoagulants & plasma expanders.
  • Antiseptics, disinfectants, sterilants, & astringents.
  • Purgatives, laxatives & antidiarrhoeal agents.

6. Various classes of therapeutic agents

A detailed study of the following classes with respect to drug nomenclature, classification, physicochemical properties, mode of action [MOA], structure-activity relationships [SAR], wherever applicable, synthesis of simple & prototype molecules, drug metabolism, therapeutic uses & side effects. Drug resistance, wherever applicable, should be covered in respective
classes of drugs.

  • a. Antimalarials
  • b. Antiamoebic agents.
  • c. Anthelmintic agents.
  • d. Antibacterial sulpha drugs [only].
  • e. Quinolone antibacterials.
  • f. Antimycobacterial drugs.
  • g. Antifungal agents.
  • g. Antiviral agents including HIV & anti-HIV drugs.
  • h. Thyroid & antithyroid drugs.
  • i. Antiallergic agents.
  • j. Antiulcer agents & Proton Pump Inhibitors.
  • k. Hypoglycemic agents.

7. Different classes of therapeutic drugs

A detailed study of the following classes with respect to drug nomenclature, classification, physicochemical properties, mode of action [MOA], structure-activity relationships [SAR], wherever applicable, synthesis of simple & prototype molecules, drug metabolism, therapeutic uses & side effects. Drug resistance, wherever applicable, should be covered in respective
classes of drugs.

  • I. a. Sedative-hypnotics , b. Antiepileptic agents , c. Neuroleptics , d. Anti-anxiety drugs.
  • II. Antibiotics. Penicillins, cephalosporins & other beta-lactam antibiotics like imipenem & aztreonam. Beta-lactamase inhibitors such as clavulanic acid & sulbactam. Chloramphenicol. Tetracyclines. Aminoglycoside antibiotics. Macrolide antibiotics. Lincomycins. Polypeptide antibiotics. Anticancer antibiotics.
  • III. Steroids. Corticosteroids [gluco- & mineralocorticoids] & anti-inflammatory steroids. Sex steroids. Male & female contraceptive agents. Anabolic steroids. Anticancer agents.

8. Different classes of therapeutic drugs

A detailed study of the following classes with respect to drug nomenclature, classification, physicochemical properties, mode of action [MOA], biosynthesis, structure-activity relationships [SAR], wherever applicable, synthesis of simple & prototype molecules, drug  metabolism, therapeutic uses & side effects. Drug resistance, wherever applicable, in respective classes of drugs.

  • I. Narcotic [centrally acting] analgesics [analgetics]. Morphine & all its structural modifications [peripheral & nuclear]. Narcotic agonists & antagonists [dual & pure]. Non-narcotic analgesics [NSAIDS]. Difference between narcotic & non-narcotic agents.
  • II. Adrenergic drugs. Neurotransmitters & their role. General & specific adrenergic agonists & antagonists [up to alpha-2 & beta-2 only].
  • III. Cholinergic agents. Muscarinic & nicotinic cholinergic agonists & antagonists [up to M2 & N2]. Neuronal [transmission] blockers.
  • IV. Drugs used in neuromuscular disorders. Drugs used in the treatment of Parkinson’s disease. Central & peripheral muscle relaxants.
  • V. Hypertensive, antihypertensive, & antianginal agents.
  • VI. Diuretics.
  • VII. Eicosanoids. Prostaglandins, prostacyclins, & thromboxanes. Their biochemical role, biosynthesis, & inhibitors.

9. Introduction to quantitative structure-activity relationship. [QSAR]. Linear free energy relationship. Hammett’s equation. Use of substituent constants such as π, σ, Es, & physicochemical parameters such as pKa, partition coefficient, Rm, chemical shifts, molar refractivity, simple & valance molecular connectivity to indicate electronic effects, lipophilic effects, & steric effects. Introduction, methodology, advantages &
disadvantages/limitations of Hansch analysis.

10. Asymmetric synthesis. Chirality, chiral pool, sources of various naturally available chiral compounds. Eutomers, distomers, eudismic ratio. Enantioselectivity &
enantiospecificity. Enantiomeric & diastereomeric excess. Prochiral molecules. Asymmetric synthesis of captopril & propranolol.

11. Combinatorial chemistry. Introduction & basic terminology. Databases & libraries. Solid phase synthesis technique. Types of supports & linkers, Wang, Rink, & dihydropyran derivatized linkers. Reactions involving these linkers. Manual parallel & automated parallel synthesis. Houghton’s tea bag method, micromanipulation, recursive deconvolution. Mix & split method for the synthesis of tripeptides. Limitations of
combinatorial synthesis. Introduction to throughput screening.

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