Hypnotic Drugs MCQs with Answers Free 2022

Hypnotics which also known as Sleep Medication, are medications used to induce, extend, or improve the quality of sleep, and to reduce wakefulness during sleep. The most commonly used hypnotics include benzodiazepine receptor agonists (BzRAs), antidepressants, antipsychotics, antihistamines, and melatonin (or melatonin receptor agonists)

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This is the Post in which you will get the a Number of Multiple Choice Questions  regarding Hypnotic Drugs. It is mainly useful for M.Sc level entrances  of  Pharmacy such as Graduate Pharmacy Aptitude Test (GPAT), B-Pharma, D-Pharma, NIPER etc. So , Revise and make a strong grip on this Chapter or Topic of Hypnotic Drugs by  Practicing these Multiple Choice Questions


Hypnotic Drugs MCQs with Answers Free 2022 [Practice Now]


  1. Hypnotic drugs are used to treat:
    a) Psychosis
    b) Sleep disorders
    c) Narcolepsy
    d) Parkinsonian disorders
  2. Hypnotic drugs should:
    a) Reduce anxiety and exert a calming effect
    b) Induce absence of sensation
    c) Produce drowsiness, encourage the onset and maintenance of sleep
    d) Prevent mood swings in patients with bipolar affective disorders
  3. Which of the following chemical agents are used in the treatment of insomnia?
    a) Benzodiazepines
    b) Imidazopyridines
    c) Barbiturates
    d) All of the above
  4. Select a hypnotic drug, which is a benzodiazepine derivative:
    a) Zolpidem
    b) Flurazepam
    c) Secobarbital
    d) Phenobarbitone
  5. Tick a hypnotic agent – a barbituric acid derivative:
    a) Flurazepam
    b) Zaleplon
    c) Thyopental
    d) Triazolam
  6. Select a hypnotic drug, which is an imidazopyridine derivative:
    a) Pentobarbital
    b) Temazepam
    c) Zolpidem
    d) Chloral hydrate
  7. Which of the following hypnotic agents is absorbed slowly?
    a) Phenobarbital
    b) Flurazepam
    c) Triazolam
    d) Temazepam
  8. Which of the following barbiturates is an ultra-short-acting drug?
    a) Secobarbital
    b) Amobarbital
    c) Thiopental
    d) Phenobarbital
  9. Indicate the barbituric acid derivative, which has 4-5 days elimination half-life:
    a) Secobarbital
    b) Thiopental
    c) Phenobarbital
    d) Amobarbital
  10. Indicate the hypnotic benzodiazepine, which has the shortest elimination half-life:
    a) Temazepam
    b) Triazolam
    c) Flurazepam
    d) Diazepam
  11. Which of the following hypnotic drugs is more likely to cause cumulative and residual effects?
    a) Zolpidem
    b) Temazepam
    c) Phenobarbital
    d) Triazolam
    35
  12. Which of the following hypnotic drugs increases the activity of hepatic drug-metabolizing enzyme systems?
    a) Phenobarbital
    b) Zolpidem
    c) Flurazepam
    d) Zaleplon
  13. Hepatic microsomal drug-metabolizing enzyme induction leads to:
    a) Barbiturate tolerance
    b) Cumulative effects
    c) Development of physical dependence
    d) “hangover” effects
  14. Hypnotic benzodiazepines are more powerful enzyme inducers than barbiturates.
    a) True
    b) False
  15. Indicate the hypnotic drug, which does not change hepatic drug-metabolizing enzyme activity?
    a) Flurazepam
    b) Zaleplon
    c) Triazolam
    d) All of the above
  16. Barbiturates increase the rate of metabolism of:
    a) Anticoagulants
    b) Digitalis compounds
    c) Glucocorticoids
    d) All of the above
  17. Which of the following agents inhibits hepatic metabolism of hypnotics?
    a) Flumasenil
    b) Cimetidin
    c) Phenytoin
    d) Theophylline
  18. Which of the following factors can influence the biodisposition of hypnotic agents?
    a) Alterations in the hepatic function resulting from a disease
    b) Old age
    c) Drug-induced increases or decreases in microsomal enzyme activities
    d) All of the above
  19. Which of the following hypnotics is preferred for elderly patients?
    a) Phenobarbital
    b) Flurozepam
    c) Temazepam
    d) Secobarbital
  20. Which of the following hypnotics is preferred in patients with limited hepatic function?
    a) Zolpidem
    b) Amobarbital
    c) Flurozepam
    d) Pentobarbital
  21. Indicate the mechanism of barbiturate action (at hypnotic doses):
    a) Increasing the duration of the GABA-gated Cl- channel openings
    b) Directly activating the chloride channels
    c) Increasing the frequency of Cl- channel opening events
    d) All of the above
  22. Imidazopyridines are:
    a) Partial agonists at brain 5-TH1A receptors
    b) Selective agonists of the BZ1 (omega1) subtype of BZ receptors
    c) Competitive antagonists of BZ receptors
    d) Nonselective agonists of both BZ1 and BZ2 receptor subtypes
  23. Which of the following hypnotic agents is a positive allosteric modulator of GABAA receptor function?
    a) Zaleplon
    b) Flurazepam
    c) Zolpidem
    d) All of the above
  24. Indicate a hypnotic drug – a selective agonist at the BZ1 receptor subtype:
    a) Flurazepam
    b) Zolpidem
    c) Triazolam
    d) Flumazenil
  25. Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes?
    a) Zaleplon
    b) Phenobarbital
    c) Flurazepam
    d) Zolpidem
  26. Indicate the competitive antagonist of BZ receptors:
    a) Flumazenil
    b) Picrotoxin
    c) Zolpidem
    d) Temazepam
  27. Flumazenil blocks the actions of:
    a) Phenobarbital
    b) Morphine
    c) Zolpidem
    d) Ethanol
  28. Indicate the agent, which interferes with GABA binding:
    a) Flurazepam
    b) Bicuculline
    c) Thiopental
    d) Zolpidem
  29. Which of the following agents blocks the chloride channel directly?
    a) Secobarbital
    b) Flumazenil
    c) Zaleplon
    d) Picrotoxin
  30. Which of the following agents is preferred in the treatment of insomnia?
    a) Barbiturates
    b) Hypnotic benzodiazepines
    c) Ethanol
    d) Phenothiazide
  31. Barbiturates are being replaced by hypnotic benzodiazepines because of:
    a) Low therapeutic index
    b) Suppression in REM sleep
    c) High potential of physical dependence and abuse
    d) All of the above
  32. Which of the following benzodiazepines is used mainly for hypnosis?
    a) Clonozepam
    b) Lorazepam
    c) Flurazepam
    d) Midazolam
  33. Indicate the main claim for an ideal hypnotic agent:
    a) Rapid onset and sufficient duration of action
    b) Minor effects on sleep patterns
    c) Minimal “hangover” effects
    d) All of the above
  34. Which stage of sleep is responsible for the incidence of dreams?
    a) REM sleep
    b) Slow wave sleep
    c) Stage 2NREM sleep
    d) All of the above
  35. During slow wave sleep (stage 3 and 4 NREM sleep):
    a) Dreams occur
    b) The secretion of adrenal steroids is at its highest
    c) Somnambulism and nightmares occur
    d) The secretion of somatotropin is at its lowest
  36. All of the hypnotic drugs induce:
    a) Increase the duration of REM sleep
    b) Decrease the duration of REM sleep
    c) Do not alter the duration of REM sleep
    37
    d) Increase the duration of slow wave sleep
  37. Which of the following hypnotic drugs causes least suppression of REM sleep?
    a) Flumazenil
    b) Phenobarbital
    c) Flurazepam
    d) Secobarbital
  38. Although the benzodiazepines continue to be the agents of choice for insomnia, they have:
    a) The possibility of psychological and physiological dependence
    b) Synergistic depression of CNS with other drugs (especially alcohol)
    c) Residual drowsiness and daytime sedation
    d) All of the above
  39. Hypnotic benzodiazepines can cause:
    a) A dose-dependent increase in both REM and slow wave sleep
    b) Do not change sleep patterns
    c) A dose-dependent decrease in both REM and slow wave sleep
    d) A dose-dependent increase in REM sleep and decrease in slow wave sleep
  40. Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?
    a) Triazolam
    b) Flurazepam
    c) Temazepam
    d) All of the above
  41. Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness,
    dysphoria, and mental or motor depression the following day?
    a) Temazepam
    b) Triazolam
    c) Flurazepam
    d) None of the above
  42. Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:
    a) Thiopental
    b) Zolpidem
    c) Flurazepam
    d) Phenobarbital
  43. Which of the following statements is correct for zolpidem?
    a) Causes minor effects on sleep patterns
    b) The risk of development of tolerance and dependence is less than with the use of hypnotic benzodiazepines
    c) Has minimal muscle relaxing and anticonvulsant effects
    d) All of the above
  44. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
    a) Flurazepam
    b) Triazolam
    c) Zaleplon
    d) None of the above
  45. Zolpidem and zaleplon have effectiveness similar to that of hypnotic benzodiazepines in the management of sleep
    disorders.
    a) True
    b) False
  46. Which of the following hypnotic drugs is used intravenously as anesthesia?
    a) Thiopental
    b) Phenobarbital
    c) Flurazepam
    d) Zolpidem
  47. Indicate the usual cause of death due to overdose of hypnotics:
    a) Depression of the medullar respiratory center
    b) Hypothermia
    c) Cerebral edema
    d) Status epilepticus
  48. Toxic doses of hypnotics may cause a circulatory collapse as a result of:
    a) Blocking alfa adrenergic receptors
    b) Increasing vagal tone
    c) Action on the medullar vasomotor center
    d) All of the above

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Hypnotic Drugs MCQs with Answers Free 2022 : ANSWER KEY

If you find any Question or Answer wrong , then you can mention in the comment below.

01. –   b   11. –   c   21. –   a   31. –   d    41. –  c
02. –   c   12. –   a   22. –   b   32. –   c    42. –  b
03. –   d   13. –   a   23. –   d   33. –   d   43. –  d
04. –   b   14. –   b   24. –   b   34. –   a   44. –  c
05. –   c   15. –   d   25. –   c   35. –   c   45. –  a
06. –   c   16. –   d   26. –   a   36. –   b   46. –  a
07. –   d   17. –   b   27. –   c   37. –   c   47. –  a
08. –   c   18. –   d   28. –   b   38. –   d   48. –  c
09. –   c   19. –   c   29. –   d   39. –   c 
10. –   b   20. –   a   30. –   b   40. –   a

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